Although Latinos are now the largest non-majority group in the United States, existing research on white attitudes toward Latinos has focused almost exclusively on attitudes toward immigration. This book changes that. It argues that such accounts fundamentally underestimate the political power of whites’ animus toward Latinos and thus miss how conflict extends well beyond immigration to issues such as voting rights, criminal punishment, policing, and which candidates to support. Providing historical and cultural context and drawing on rich survey and experimental evidence, the authors show that Latino racism-ethnicism is a coherent belief system about Latinos that is conceptually and empirically distinct from other forms of out-group hostility, and from partisanship and ideology. Moreover, animus toward Latinos has become a powerful force in contemporary American politics, shaping white public opinion in elections and across a number of important issue areas – and resulting in policies that harm Latinos disproportionately.