Copper-Catalyzed Electrophilic Amination of Sp2 and Sp3 C?H Bonds

This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.

Author	Stacey L. McDonald
Book Series	Springer Theses
Format	Ebook
ISBN	9783319388779
Language	English
Pages	119
Publication Date	08-17-2016
Publisher	Springer

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