The new edition of *The Best of Five MCQS for the European Specialty Examination* *in Gastroenterology and Hepatology* is a question book designed to assist in preparations for the European Specialty Examination in Gastroenterology and Hepatology (ESEGH). The book has been fully updated to reflect the new examination introduced in 2018 and the most recent guidelines. Containing a foreword by Sir Ian Gilmore, former president of both the British Society for Gastroenterology and the Royal College of Physicians, the book adopts the same Best of Five question format used in the ESEGH and covers the breadth of the curriculum. It has been designed to exactly match the relative proportion of questions on each topic area found in the examination. Each of the 300 questions contained in the book is accompanied by an answer, a set of three succinct bullet points of key ‘take-home’ messages, and a short summary of the relevant background, evidence-base and up-to-date European guidelines. The book ends with a chapter of 50 questions, which again matches the proportions of topic areas found in the ESEGH, and is designed to act as a mock-examination for use in the final stages of preparation.