This book presents an original approach to the study of psychiatry that is based on a justified epistemological position, which demands that both the natural and the human/social sciences are necessary in developing our understanding. Psychiatry as a medical specialism was constructed in the nineteenth century through the interplay of both the natural sciences and the human/social sciences. This interplay has created a hybrid discipline that spans biological and socio-cultural-historical domains, which has raised challenges for its understanding and research. This book focuses on one of the principal challenges – how can we explore mental symptoms and mental disorders as complexes of neurobiology on the one hand and meaning on the other? The chapters in this book, dedicated to Germán E Berrios, founder of the Cambridge school of psychopathology, tackles distinctive aspects of psychopathology or related areas. By means of a combination of approaches, chapters seek to unfold another element in our understanding of this field as well as raise new directions for its further study. *Rethinking Psychopathology* is a valuable resource for clinical psychologists and psychotherapists, psychological researchers, historians of psychology, cultural psychologists, critical psychologists, social scientists, philosophers of psychology, and philosophers of science.