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Synthesis of Essential Drugs
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Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs.
This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms.
Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry.
Purchase this item and get 9 Points - a worth of $0.90Preface p. vii1 General Anesthetics p. 11.1 Inhalation anesthetics p. 11.2 Noninhalation anesthetics p. 42 Local Anesthetics p. 92.1 Local Anesthetics of the Aminoether Series p. 122.2 Local Anesthetics of the Aminoamide Series p. 142.3 Topical Anesthetics p. 173 Analgesics p. 193.1 Opioid Analgesics p. 203.1.1 Agonists p. 213.1.2 Mixed agonists/antagonists p. 333.1.3 Opioid antagonists p. 373.2 Nonsteroid Anti-Inflammatory Drugs and Anti-Fever Analgesics p. 383.2.1 Salicylic acid derivatives p. 393.2.2 Pyrazolonees p. 403.2.3 p-Aminophenol derivatives p. 423.2.4 Anthranylic acid derivatives p. 423.2.5 Propionic acid derivatives p. 443.2.6 Acetic acid derivatives p. 463.2.7 Indolyl/indeneacetic acids p. 473.2.8 Oxicames p. 514 Soporific Agents (Hypnotics and Sedative Drugs) p. 574.1 Barbiturates p. 584.1.1 Long-acting barbiturates p. 594.1.2 Intermediate-acting barbiturates p. 604.1.3 Short-action barbiturates p. 614.1.4 Ultrashort-action barbiturates p. 624.2 Benzodiazepines p. 624.3 Other Hypnotics and Sedative Drugs p. 655 Anxiolytics (Tranquilizers) p. 695.1 Benzodiazepines p. 695.2 Anxiolytic of Nonbenzodiazepine Structures p. 786 Antipsychotics (Neuroleptics) p. 836.1 Phenothiazine derivatives p. 846.2 Thioxanthene derivatives p. 886.3 Butyrophenone derivatives p. 916.4 Dihydroindolone derivatives p. 936.5 Dibenzoxazepine and dibenzdiazepine derivatives p. 946.6 Diphenylbutylpiperidine derivatives p. 966.7 Other neuroleptics p. 996.8 Lithium derivatives p. 997 Antidepressants p. 1037.1 Tricyclic Antidepressants p. 1047.1.1 Tertiary amines-representatives of tricyclic antidepressants p. 1047.1.2 Secondary amines-representatives of tricyclic antidepressants p. 1077.2 Monoaminooxidase Inhibitors p. 1107.3 Second-Generation Antidepressants (Atypical Antidepressants) p. 1127.4 Amphetamines and other CNS Stimulators p. 1148 Central Nervous System Stimulants p. 1178.1 Psychomotor Stimulants p. 1178.1.1 Methylxanthines p. 1178.1.2 Amphetamines, methylphenidate, and pemoline p. 1188.2 Respiratory Stimulants or Analeptics p. 1218.3 Appetite Suppressants or Anorectics p. 1239 Antiepileptic Drugs p. 1259.1 Hydantoin Derivatives p. 1269.2 Barbiturates p. 1279.3 Succinimides p. 1289.4 Valproic Acid p. 1299.5 Carbamazepine p. 1299.6 Benzodiazepines p. 1309.7 Acetazolamide p. 1319.8 Oxazolidines p. 13110 Antiparkinsonian Drugs p. 13510.1 Drugs Affecting the Dopaminergic Systems of the Brain p. 13510.2 Anticholinergic Drugs (Central Cholinoblockers) p. 13811 Adrenergic (Sympathomimetic) Drugs p. 14311.1 Direct-Acting Agonists p. 14611.1.1 Drugs stimulating [alpha]- and [beta]-adrenoreceptors p. 14611.1.2 Drugs stimulating predominantly [beta]-adrenoreceptors p. 14811.1.3 Drugs stimulating predominantly [alpha]-adrenoreceptors p. 15311.1.4 Antiedema sympathomimetics p. 15311.2 Indirect-Acting Agonists p. 15511.3 Agonists of Mixed Action p. 15512 Adrenoblocking Drugs p. 16112.1 [beta]-Adrenoblockers p. 16212.2 [alpha]-Adrenoblockers p. 16712.2.1 Long-lasting noncompetitive antagonists p. 16812.2.2 Nonselective, reversible competitive adrenoblockers p. 16912.2.3 Reversible, competitive [alpha subscript 1]-selective adrenoblockers p. 17012.2.4 Ergot alkaloids (alkaloids of ergot) p. 17112.2.5 Selective [alpha subscript 2]-adrenoblockers p. 17212.3 Adrenergic Neuron Blockers p. 17213 Cholinomimetics p. 17913.1 Direct-Acting Cholinomimetics p. 18013.1.1 Choline esters p. 18013.1.2 Natural muscarinic alkaloids p. 18313.1.3 Natural nicotinic alkaloids p. 18513.2 Indirect-Acting Cholinomimetics p. 18613.2.1 Reversible cholinesterase inhibitors p. 18713.2.2 Carbamates p. 18713.2.3 Quaternary amines p. 18913.2.4 Irreversible cholinesterase inhibitors p. 19013.2.5 Other organophosphorous cholinesterase inhibitors p. 19114 Anticholinergic Drugs p. 19514.1 Antimuscarinic Drugs p. 19514.1.1 Alkaloids p. 19614.1.2 Anticholinergics of the quaternary amine series p. 19814.1.3 Antiparkinsonian drugs of the quaternary amine series p. 20214.1.4 Antispasmodics of the tertiary series p. 20214.1.5 Mydriatics of the tertiary amine series p. 20414.2 Ganglioblocking Substances p. 20515 Muscle Relaxants p. 20915.1 Neuromuscular Junction Blocking Agents p. 21015.1.1 Antidepolarizing neuromuscular junction blockers p. 21015.1.2 Depolarizing neuromuscular blockers p. 21315.2 Direct-Acting Muscle Relaxants p. 21415.3 Centrally Acting Muscle Relaxants p. 21516 Antihistamine Drugs p. 21916.1 H[subscript 1] Antihistamine Drugs p. 22116.1.1 Aminoalkyl esters p. 22216.1.2 Ethylenediamines p. 22416.1.3 Alkylamines p. 22516.1.4 Piperazines p. 22616.1.5 Phenothiazines p. 22716.1.6 Piperidines p. 22816.2 H[subscript 2] Receptor Antagonists p. 23017 Cardiotonic Drugs p. 23717.1 Cardiac Glycosides p. 23817.2 Other Positive Inotropic Drugs p. 24118 Antiarrhythmic Drugs p. 24518.1 Group I Drugs p. 24618.1.1 Subgroup IA p. 24618.1.2 Subgroup IB p. 24818.1.3 Subgroup IC p. 25018.2 Group II Drugs p. 25118.3 Group III Drugs p. 25218.4 Group IV Drugs p. 25319 Antianginal Drugs p. 25719.1 Nitrates and Nitrites p. 25719.2 [beta]-Adrenoblockers p. 25919.3 Calcium channel blockers p. 26119.4 Other drugs p. 26520 Hypolipidemic Agents p. 26920.1 Bile acid sequesters p. 27020.2 Drugs that inhibit cholesterol synthesis p. 27220.3 Other drugs p. 27521 Diuretics p. 27721.1 Osmotic Diuretics p. 27721.2 Carbonic anhydrase Activity Suppressing Diuretics p. 27821.3 Thiazide Diuretics p. 28021.3.1 Drugs related to thiazide diuretics p. 28421.4 Loop Diuretics p. 28621.5 Potassium Sparing Diuretics p. 28822 Antihypertensive Drugs p. 29522.1 Diuretics p. 29622.1.1 Thiazide diuretics p. 29722.1.2 Thiazide-related drugs p. 29722.1.3 Potassium sparing diuretics p. 29722.2 [beta]-adrenoblockers p. 29822.3 Centrally acting adrenergic drugs (sympatholytics) p. 29922.4 Peripherally acting sympatholytics ([alpha]-adrenoblockers) p. 30022.4.1 Reversible competitive [alpha subscript 1]-selective adrenoblockers p. 30122.4.2 Adrenergic neuron blockers p. 30122.5 Calcium channel blockers p. 30322.6 Myotropic hypotensive drugs p. 30422.7 Angiotensin-converting enzyme inhibitors p. 30522.8 Calcium channel activators p. 30823 Drugs for Treating Respiratory System Illnesses p. 31123.1 Antiedema, Vasoconstricting Drugs p. 31123.2 Anticough and Expectorant Agents p. 31223.2.1 Narcotic anticough drugs p. 31223.2.2 Non-narcotic anticough drugs p. 31323.2.3 Expectorant drugs p. 31323.3 Bronchodilators (Broncholytics) p. 31423.3.1 Methylxanthines p. 31423.3.2 Anticholinergic drugs p. 31623.3.3 Inhibitors of allergy mediator release p. 31623.3.4 Corticosteroids p. 31723.3.5 Adrenergic drugs ([beta subscript 2]-receptor agonists, sympathomimetics) p. 31824 Anticoagulants, Antiaggregants, Thrombolytics, and Hemostatics p. 32324.1 Anticoagulants p. 32424.1.1 Direct-acting coagulants or parenteral anticoagulants p. 32424.1.2 Direct-acting coagulants, or enteral anticoagulants p. 32524.2 Antiaggregants p. 32824.3 Fibrinolytics (Thrombolytics) p. 33024.4 Hemostatics (Procoagulants) p. 33224.4.1 Systemic hemostatics p. 33224.4.2 Local procoagulants p. 33325 Thyroid Hormone and Antithyroid Drugs p. 33725.1 Drugs for Treating Hypothyroidism p. 33825.2 Drugs for Treating Hyperthyroidism p.
| Book Author: | Ruben Vardanyan, Victor Hruby |
|---|---|
| Language: | English |
| Pages: | 523 |
| Publisher: | Elsevier |
| Publication Date: | 2006 |
| ISBN-13: | 9780444521668 |
| Format: | iPhones/iPads/Mac (Apple Books), Androids/PCs (Google Play), Kobo, Nook, Kindle |
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